Princípios de Farmacologia - A Base Fisiopatológica da Farmacolo

Princípios de Farmacologia - A Base Fisiopatológica da Farmacolo

(Parte 1 de 5)

Os autores deste livro e a EDITORA GUANABARA KOOGAN LTDA. empenharam seus melhores esforços para assegurar que as informações e os procedimentos apresentados no texto estejam em acordo com os padrões aceitos à época da publicação, e todos os dados foram atualizados pelos autores até a data da entrega dos originais à editora. Entretanto, tendo em conta a evolução das ciências da saúde, as mudanças regulamentares governamentais e o constante fluxo de novas informações sobre terapêutica medicamentosa e reações adversas a fármacos, recomendamos enfaticamente que os leitores consultem sempre outras fontes fidedignas, de modo a se certificarem de que as informações contidas neste livro estão corretas e de que não houve alterações nas dosagens recomendadas ou na legislação regulamentadora. Adicionalmente, os leitores podem buscar por possíveis atualizações da obra em http://gen-io.grupogen.com.br.

Os autores e a editora envidaram todos os esforços no sentido de se certificarem de que a escolha e a posologia dos medicamentos apresentados neste compêndio estivessem em conformidade com as recomendações atuais e com a prática em vigor na época da publicação. Entretanto, em vista da pesquisa constante, das modificações nas normas governamentais e do fluxo contínuo de informações em relação à terapia e às reações medicamentosas, o leitor é aconselhado a checar a bula de cada fármaco para qualquer alteração nas indicações e posologias, assim como para maiores cuidados e precauções. Isso é particularmente importante quando o agente recomendado é novo ou utilizado com pouca frequência.

Os autores e a editora se empenharam para citar adequadamente e dar o devido crédito a todos os detentores de direitos autorais de qualquer material utilizado neste livro, dispondo-se a possíveis acertos posteriores caso, inadvertida e involuntariamente, a identificação de algum deles tenha sido omitida.

Traduzido de: Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy, Third Edition Copyright © 2012 Lippincott Williams & Wilkins All rights reserved. 2001 Market Street Philadelphia, PA 19103 USA LWW.com Published by arrangement with Lippincott Williams & Wilkins, Inc., USA. Lippincott Williams & Wilkins/Wolters Kluwer Health did not participate in the translation of this title. Direitos exclusivos para a língua portuguesa Copyright © 2014 by

Uma editora integrante do GEN | Grupo Editorial Nacional Travessa do Ouvidor, 1

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Ficha catalográfica P952

Princípios de farmacologia: a base fisiopatológica da farmacoterapia/editor-chefe David E. Golan, co-editor Armen H. Tashjian,

Jr., editores associados Ehrin J. Armstrong, revisão técnica Lenita Wannmacher; traduzido por Patricia Lydie Voeux, Maria de Fátima Azevedo. – [3. ed.] – Rio de Janeiro: Guanabara Koogan, 2014. il.

Tradução de: Principles of pharmacology: the pathophysiologic basis of drug therapy, ISBN 978-85-277-2599-6

1. Farmacologia. 2. Fisiopatologia. 3. Quimioterapia. I. Golan, David E.

Amigo, mentor, colega.

O farmacologista dos farmacologistas. Seu espírito vive em nós e nesta obra. Os autores

Colaboradores

Gail K. Adler, MD, PhD Associate Professor of Medicine

Harvard Medical School Associate Physician Division of Endocrinology, Diabetes and Hypertension Department of Medicine Brigham and Women’s Hospital Boston, Massachusetts

Ali Alikhan, MD Resident, Department of Dermatology

Mayo Clinic Rochester, Minnesota

Seth L. Alper, MD, PhD Professor of Medicine

Harvard Medical School Renal Division and Molecular and Vascular Medicine Division Department of Medicine Beth Israel Deaconess Medical Center Boston, Massachusetts

April W. Armstrong, MD, MPH Assistant Professor of Dermatology

Director, Dermatology Clinical Research Unit Director, Teledermatology Program University of California Davis Health System Davis, California

Ehrin J. Armstrong, MD, MSc Clinical Fellow in Cardiology

University of California, San Francisco San Francisco, California

Sarah R. Armstrong, MS, DABT Senior Scientist

Cambridge Environmental, Inc. Cambridge, Massachusetts

Ramy A. Arnaout, MD, DPhil Instructor in Pathology

Harvard Medical School Associate Director, Clinical Microbiology Department of Pathology Beth Israel Deaconess Medical Center Boston, Massachusetts

Alireza Atri, MD, PhD Clinical Instructor in Neurology

Harvard Medical School Assistant in Neurology Massachusetts General Hospital Boston, Massachusetts Deputy Director Geriatric Research, Education and Clinical Center Bedford, Massachusetts

Jerry Avorn, MD Professor of Medicine

Harvard Medical School Chief, Division of Pharmacoepidemiology Brigham and Women’s Hospital Boston, Massachusetts

Quentin J. Baca, PhD MD Candidate, Harvard-MIT MD-PhD Program

Department of Biological Chemistry and Molecular Pharmacology

Harvard Medical School Boston, Massachusetts

David A. Barbie, MD Assistant Professor of Medicine

Harvard Medical School Associate Physician Department of Medical Oncology Dana-Farber Cancer Institute Boston, Massachusetts

Robert L. Barbieri, MD Kate Macy Ladd Professor of Obstetrics, Gynecology and Reproductive Biology

Department of Obstetrics, Gynecology and Reproductive Biology Harvard Medical School Chairman, Department of Obstetrics and Gynecology Brigham and Women’s Hospital Boston, Massachusetts

Miles Berger, MD, PhD Resident, Department of Anesthesiology

Duke University Medical Center Durham, North Carolina

Mallar Bhattacharya, MD, MSc Clinical Instructor of Medicine

University of California, San Francisco San Francisco, California

Lauren K. Buhl, MB PhD Candidate

Department of Brain and Cognitive Sciences Massachusetts Institute of Technology Cambridge, Massachusetts MD Candidate Division of Health Sciences and Technology Harvard Medical School Boston, Massachusetts

Cindy Chambers, MAS, MPH MD Candidate

University of California, Davis Sacramento, California

Michael S. Chang, MD Fellowship Director

Adult and Pediatric Spine Surgery Sonoran Spine Center Phoenix, Arizona

Lily Cheng, BS Co-author for Drug Summary Tables

MD Candidate University of California, Davis Sacramento, California

William W. Chin, MD Bertarelli Professor in Translational Medical Science

Executive Dean for Research Harvard Medical School Professor of Medicine Brigham and Women’s Hospital Boston, Massachusetts

Deborah Yeh Chong, MD Assistant Professor

Department of Ophthalmology University of Texas Southwestern Medical School Dallas, Texas

Janet Chou, MD Instructor, Department of Pediatrics

Harvard Medical School Assistant in Medicine Department of Immunology Children’s Hospital Boston Boston, Massachusetts

David E. Clapham, MD, PhD Aldo R. Castañeda Professor of Cardiovascular Research

Professor of Neurobiology Harvard Medical School Chief, Basic Cardiovascular Research Department of Cardiology Children’s Hospital Boston Boston, Massachusetts

Donald M. Coen, PhD Professor of Biological Chemistry and Molecular Pharmacology

Harvard Medical School Boston, Massachusetts

David E. Cohen, MD, PhD Robert H. Ebert Associate Professor of Medicine and Health Sciences and Technology

Director, Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology Harvard Medical School Director of Hepatology Division of Gastroenterology, Hepatology and Endoscopy Department of Medicine Brigham and Women’s Hospital Boston, Massachusetts

Michael W. Conner, DVM Vice President

Safety Assessment Theravance, Inc. South San Francisco, California

Susannah B. Cornes, MD Assistant Professor, Department of Neurology

University of California, San Francisco Department of Neurology UCSF Medical Center San Francisco, California

John P. Dekker, MD, PhD

Resident, Department of Pathology Massachusetts General Hospital Boston, Massachusetts

George D. Demetri, MD Associate Professor of Medicine

Department of Medical Oncology Harvard Medical School Director, Ludwig Center at Dana-Farber/Harvard Cancer Center Department of Experimental Therapeutics and Medical Oncology Dana-Farber Cancer Institute Boston, Massachusetts

Catherine Dorian-Conner, PharmD, PhD Consultant in Toxicology

Half Moon Bay, California

David M. Dudzinski, MD, JD Clinical Fellow in Medicine

Harvard Medical School Fellow, Department of Cardiology Massachusetts General Hospital Boston, Massachusetts

Stuart A. Forman, MD, PhD Associate Professor of Anaesthesia

Harvard Medical School Boston, Massachusetts

David A. Frank, MD, PhD Associate Professor of Medicine

Harvard Medical School Associate Professor Departments of Medicine and Medical Oncology Dana-Farber Cancer Institute Boston, Massachusetts

Joshua M. Galanter, MD Fellow, Department of Medicine

University of California, San Francisco San Francisco, California

Rajesh Garg, MD Assistant Professor of Medicine

Harvard Medical School Associate Physician Division of Endocrinology, Diabetes and Hypertension Department of Medicine Brigham and Women’s Hospital Boston, Massachusetts

David E. Golan, MD, PhD Professor of Biological Chemistry and Molecular Pharmacology

Professor of Medicine Dean for Graduate Education Special Advisor for Global Programs Harvard Medical School Scholar and Founding Member, The Academy at Harvard Medical School Physician, Hematology Division, Brigham and Women’s Hospital and Dana-Farber Cancer Institute Department of Biological Chemistry and Molecular Pharmacology, Department of Medicine Harvard Medical School Boston, Massachusetts

Mark A. Goldberg, MD Associate Professor of Medicine

Harvard Medical School Boston, Massachusetts Senior Vice President Clinical Development Genzyme Corporation Cambridge, Massachusetts

Laura C. Green, PhD, DABT Senior Scientist and President

Cambridge Environmental, Inc. Cambridge, Massachusetts

Edmund A. Griffin, Jr Resident Physician

Department of Psychiatry Columbia University New York State Psychiatric Institute New York, New York

Robert S. Griffin, MD Resident, Department of Anesthesia, Critical Care, and Pain Medicine

Massachusetts General Hospital Boston, Massachusetts

F. Peter Guengerich, PhD Professor, Department of Biochemistry

Vanderbilt University School of Medicine Nashville, Tennessee

Brian B. Hoffman, MD Professor of Medicine

Harvard Medical School Physician, Department of Medicine VA Boston Healthcare System Boston, Massachusetts

David C. Hooper, MD Professor of Medicine

Harvard Medical School Chief, Infection Control Unit Massachusetts General Hospital Boston, Massachusetts

David L. Hutto, DVM, PhD, DACVP Senior Director, Drug Safety

Eisai, Inc. Andover, Massachusetts

Louise C. Ivers, MD, MPH, DTM&H Assistant Professor of Medicine

Harvard Medical School

Associate Physician Department of Medicine Brigham and Women’s Hospital Boston, Massachusetts

Daniel Kahne, PhD Professor of Chemistry and Chemical Biology

Harvard University Cambridge, Massachusetts

Ursula B. Kaiser, MD Associate Professor of Medicine

Harvard Medical School Chief, Division of Endocrinology, Diabetes and Hypertension Brigham and Women’s Hospital Boston, Massachusetts

Lloyd B. Klickstein, MD, PhD Head of Translational Medicine

New Indication Discovery Unit Novartis Institutes for Biomedical Research Cambridge, Massachusetts

Alexander E. Kuta, PhD Vice President, Regulatory Affairs

AMAG Pharmaceuticals Lexington, Massachusetts

Joseph C. Kvedar, MD Associate Professor

Department of Dermatology Harvard Medical School Dermatologist Department of Dermatology Massachusetts General Hospital Boston, Massachusetts

Robert S. Langer, ScD David H. Koch Institute Professor

Departments of Chemical Engineering and Bioengineering Massachusetts Institute of Technology Cambridge, Massachusetts Senior Research Associate Children’s Hospital Boston Boston, Massachusetts

Stephen C. Lazarus, MD Professor of Medicine

Division of Pulmonary and Critical Care Medicine Director, Training Program in Pulmonary and Critical Care Medicine University of California, San Francisco San Francisco, California

Benjamin Leader, MD, PhD Chief Executive Officer

ReproSource Woburn, Massachusetts

Eng H. Lo, PhD Professor of Neuroscience

Harvard Medical School Director, Neuroprotection Research Laboratory Departments of Radiology and Neurology Massachusetts General Hospital Boston, Massachusetts

Daniel H. Lowenstein, MD Professor, Department of Neurology

University of California, San Francisco Director, UCSF Epilepsy Center UCSF Medical Center San Francisco, California

Tania Lupoli, AM PhD Candidate

Department of Chemistry and Chemical Biology Harvard University

Cambridge, Massachusetts

Peter R. Martin, MD Professor, Departments of Psychiatry and Pharmacology

Vanderbilt University Director, Division of Addiction Psychiatry and Vanderbilt Addiction Center Vanderbilt University Medical Center Nashville, Tennessee

Thomas Michel, MD, PhD Professor of Medicine (Biochemistry)

Harvard Medical School Senior Physician in Cardiovascular Medicine Department of Medicine Brigham and Women’s Hospital Boston, Massachusetts

Keith W. Miller, MA, DPhil Edward Mallinckrodt Professor of Pharmacology

Department of Anaesthesia Harvard Medical School Pharmacologist, Department of Anesthesia, Critical Care and Pain Medicine Massachusetts General Hospital Boston, Massachusetts

Zachary S. Morris, PhD MD Candidate, Harvard-MIT MD-PhD Program

Department of Pathology Harvard Medical School Boston, Massachusetts

Joshua D. Moss, MD Assistant Professor of Medicine

Heart Rhythm Center University of Chicago Medical Center Chicago, Illinois

Dalia S. Nagel, MD Clinical Instructor, Department of Ophthalmology

Mount Sinai School of Medicine Attending Physician Department of Ophthalmology Mount Sinai Hospital New York, New York

Robert M. Neer, MD Associate Professor of Medicine

Harvard Medical School Endocrine Unit, Department of Medicine Massachusetts General Hospital Boston, Massachusetts

Sachin Patel, MD, PhD Assistant Professor, Departments of Psychiatry and Molecular Physiology and Biophysics

Vanderbilt University Medical Center Nashville, Tennessee

Thomas P. Rocco, MD Associate Professor of Medicine

Harvard Medical School Cardiovascular Division, Brigham and Women’s Hospital Boston, Massachusetts Cardiology Section, VA Boston Healthcare System West Roxbury, Massachusetts

Bryan L. Roth, MD, PhD Michael Hooker Distinguished Professor

Department of Pharmacology University of North Carolina Chapel Hill Medical School Chapel Hill, North Carolina

Edward T. Ryan, MD Associate Professor of Medicine

Harvard Medical School Associate Professor of Immunology and Infectious Diseases Harvard School of Public Health Director, Tropical Medicine

Massachusetts General Hospital Boston, Massachusetts

Marvin Ryou, MD Instructor in Medicine

(Parte 1 de 5)

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