Farmacologia Basica e Clinica - 13ed - (LANGE)

Farmacologia Basica e Clinica - 13ed - (LANGE)

(Parte 1 de 14)

Equipe de tradução

Ademar Valadares Fonseca

Geraldo Serra

José Eduardo Ferreira de Figueiredo

Luís Fernando Marques Dorvillé Patricia Lydie Voeux

Revisão técnica desta edição

Almir Lourenço da Fonseca

Diretor-Científico do Dicionário de Especialidades Farmacêuticas (DEF).

Redator-Chefe do Jornal Brasileiro de Medicina (JBM).

Ex-Diretor da Divisão Médica do Posto de Atendimento Médico (PAM) César Pernetta da Secretária Municipal da Saúde (SMS) do Rio de Janeiro. Ex-Diretor do Serviço Médico-Assistencial da Policlínica José Paranhos Fontenelle da SMS do Rio de Janeiro.

F233 Farmacologia básica e clínica [recurso eletrônico] / Organizador,

Trevor ; [tradução: Ademar Valadares Fonsecaet al. ; revisão

Bertram G. Katzung ; Organizador Associado, Anthony J. técnica: Almir Lourenço da Fonseca]. – 13. ed. – Porto Alegre : AMGH, 2017.

Editado como livro impresso em 2017. ISBN 978-85-8055-597-4

1. Farmacologia. I. Katzung, Bertram G. I. Trevor, Anthony J.

CDU 615 Catalogação na publicação: Poliana Sanchez de Araujo – CRB 10/2094

Organizador

Bertram G. Katzung, MD, PhD

Professor Emeritus

Department of Cellular & Molecular Pharmacology University of California, San Francisco

Organizador Associado

Anthony J. Trevor, PhD

Professor Emeritus

Department of Cellular & Molecular Pharmacology University of California, San Francisco

Um livro médico LANGE

Versão impressa desta obra: 2017

Obra originalmente publicada sob o título Basic and clinical pharmacology, 13th edition ISBN 0071825053 / 9780071825054

Original edition copyright ©2015, McGraw-Hill Education Global Holdings, LLC. All rights reserved.

Portuguese language translation copyright ©2017 AMGH Editora Ltda., a Grupo A Educação S.A. company. All rights reserved.

Gerente editorial: Letícia Bispo de Lima

Colaboraram nesta edição: Coordenador editorial: Alberto Schwanke Preparação de originais: Caroline Vieira Leitura final: Tiele Patricia Machado Arte sobre capa original: Kaéle Finalizando Ideias Editoração: Estúdio Castellani

Reservados todos os direitos de publicação, em língua portuguesa, à AMGH EDITORA LTDA., uma parceria entre GRUPO A EDUCAÇÃO S.A. e McGRAW-HILL EDUCATION Av. Jerônimo de Ornelas, 670 – Santana 90040-340 Porto Alegre RS Fone: (51) 3027-7000 Fax: (51) 3027-7070

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É proibida a duplicação ou reprodução deste volume, no todo ou em parte, sob quaisquer formas ou por quaisquer meios (eletrônico, mecânico, gravação, fotocópia, distribuição na Web e outros), sem permissão expressa da Editora.

Nota

A farmacologia é uma ciência em constante evolução. À medida que novas pesquisas e a experiência clínica ampliam o nosso conhecimento, são necessárias modificações no tratamento e na farmacoterapia. Os autores desta obra consultaram as fontes consideradas confiáveis, em um esforço para oferecer informações completas e, geralmente, de acordo com os padrões aceitos à época da publicação. Entretanto, tendo em vista a possibilidade de falha humana ou de alterações nas ciências médicas, os leitores devem confirmar estas informações com outras fontes. Por exemplo, e em particular, os leitores são aconselhados a conferir a bula de qualquer medicamento que pretendam administrar, para se certificar de que a informação contida neste livro está correta e de que não houve alteração na dose recomendada nem nas contraindicações para o seu uso. Essa recomendação é particularmente importante em relação a medicamentos novos ou raramente usados.

Autores

Achilles J. Pappano, PhD

Professor Emeritus, Department of Cell Biology and Calhoun Cardiology Center, University of Connecticut Health Center, Farmington

Adrienne D. Briggs, MD

Clinical Director, Bone Marrow Transplant Program, Banner Good Samaritan Hospital, Phoenix

Alan C. Sartorelli, PhD

Alfred Gilman Professor of Pharmacology, Department of Pharmacology, Yale University School of Medicine, New Haven

Allan I. Basbaum, PhD

Professor and Chair, Department of Anatomy and W.M. Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco

Anthony J. Trevor, PhD

Professor Emeritus, Department of Cellular & Molecular Pharmacology, University of California, San Francisco

Augustus O. Grant, MD, PhD

Professor of Medicine, Cardiovascular Division, Duke University Medical Center, Durham

Bertram G. Katzung, MD, PhD

Professor Emeritus, Department of Cellular & Molecular Pharmacology, University of California, San Francisco

Betty J. Dong, PharmD, FASHP, FCCP

Professor of Clinical Pharmacy and Clinical Professor of Family and Community Medicine, Department of Clinical Pharmacy and Department of Family and Community Medicine, Schools of Pharmacy and Medicine, University of California, San Francisco

Brian S. Meldrum, MB, PhD

Professor Emeritus, GKT School of Medicine, Guy’s Campus, London

Candy Tsourounis, PharmD

Professor of Clinical Pharmacy, Medication Outcomes Center, University of California, San Francisco School of Pharmacy

Cathi E. Dennehy, PharmD

Professor, Department of Clinical Pharmacy, University of California, San Francisco School of Pharmacy

Charles DeBattista, MD

Professor of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford

Christian Lüscher, MD

Departments of Basic and Clincial Neurosciences, Medical Faculty, University Hospital of Geneva, Geneva, Switzerland

Daniel D. Bikle, MD, PhD

Professor of Medicine, Department of Medicine, and Co-Director, Special Diagnostic and Treatment Unit, University of California, San Francisco, and Veterans Affairs Medical Center, San Francisco

Daniel E. Furst, MD

Carl M. Pearson Professor of Rheumatology, Director, Rheumatology Clinical Research Center, Department of Rheumatology, University of California, Los Angeles

Daniel H. Deck, PharmD

Associate Clinical Professor, School of Pharmacy, University of California, San Francisco; Infectious Diseases Clinical Pharmacist, San Francisco General Hospital

Daniel S. Maddix, PharmD

Associate Clinical Professor of Pharmacy, University of California, San Francisco

Daniel T. Teitelbaum, MD

Adjunct Professor of Occupational and Environmental Health, Colorado School of Public Health, Denver, Colorado; and Adjunct Professor, Civil and Environmental Engineering, Colorado School of Mines, Golden, Colorado

David Robertson, MD

Elton Yates Professor of Medicine, Pharmacology and Neurology, Vanderbilt University; Director, Clinical & Translational Research Center, Vanderbilt Institute for Clinical and Translational Research, Nashville vi AuTores

Dirk B. Robertson, MD

Professor of Clinical Dermatology, Department of Dermatology, Emory University School of Medicine, Atlanta

Don Sheppard, MD

Associate Professor, Departments of Microbiology and Immunology and Medicine, McGill University; Program Director, McGill Royal College Training Program in Medical Microbiology and Infectious Diseases, Montreal

Douglas F. Lake, PhD

Associate Professor, The Biodesign Institute, Arizona State University, Tempe

Edward Chu, MD

Professor of Medicine and Pharmacology & Chemical Biology; Chief, Division of Hematology-Oncology, Deputy Director, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh

Emer M. Smyth, PhD

Associate Professor, Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia

Francis S. Greenspan, MD, FACP

Clinical Professor Emeritus of Medicine and Radiology and Chief, Thyroid Clinic, Division of Endocrinology, Department of Medicine, University of California, San Francisco

Garret A. FitzGerald, MD

Chair, Department of Pharmacology; Director, Institute for Translational Medicine and Therapeutics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia

George P. Chrousos, MD

Professor & Chair, First Department of Pediatrics, Athens University Medical School, Athens

Gideon Koren MD, FRCPC, FACMT

Director, The Motherisk Program Professor of Pediatrics, Pharmacology, Pharmacy and Medical Genetics The University of Toronto; Professor of Medicine, Pediatrics and Physiology/Pharmacology and the Ivey Chair in Molecular Toxicology The University of Western Ontario

Hakan Cakmak, MD

Department of Medicine, University of California, San Francisco

Harlan E. Ives, MD, PhD

Professor Emeritus of Medicine, Department of Medicine, University of California, San Francisco

Harry W. Lampiris, MD

Professor of Clinical Medicine, UCSF, Interim Chief, ID Section, Medical Service, San Francisco VA Medical Center

Helge Eilers, MD

Professor of Anesthesia and Perioperative Care, University of California, San Francisco

Homer A. Boushey, MD

Chief, Asthma Clinical Research Center and Division of Allergy & Immunology; Professor of Medicine, Department of Medicine, University of California, San Francisco

Howard I. Maibach, MD

Professor of Dermatology, Department of Dermatology, University of California, San Francisco

Ian A. Reid, PhD

Professor Emeritus, Department of Physiology, University of California, San Francisco

Italo Biaggioni, MD

Professor of Pharmacology, Vanderbilt University School of Medicine, Nashville

James L. Zehnder, MD

Professor of Pathology and Medicine, Pathology Department, Stanford University School of Medicine, Stanford

John A. Gray, MD, PhD

Assistant Professor, Department of Neurology, Center for Neuroscience, University of California, Davis

John P. Kane, MD, PhD

Professor of Medicine, Department of Medicine; Professor of Biochemistry and Biophysics; Associate Director, Cardiovascular Research Institute, University of California, San Francisco

John R. Horn, PharmD, FCCP

Professor of Pharmacy, School of Pharmacy, University of Washington; Associate Director of Pharmacy Services, Department of Medicine, University of Washington Medicine, Seattle

Joseph R. Hume, PhD

Emeritus Chairman of Pharmacology and Professor of Pharmacology & Physiology; University of Nevada School of Medicine, Reno, NV 89557

Joshua M. Galanter, MD

Department of Medicine, University of California, San Francisco

Kenneth Drasner, MD

Profesor of Anesthesia and Perioperative Care, University of California, San Francisco

Kenneth R. McQuaid, MD

Professor of Clinical Medicine, University of California, San Francisco; Chief of Gastroenterology, San Francisco Veterans Affairs Medical Center

AuTores vii

Kent R. Olson, MD

Clinical Professor, Departments of Medicine and Pharmacy, University of California, San Francisco; Medical Director, San Francisco Division, California Poison Control System

Lisa G. Winston, MD

Associate Professor, Department of Medicine, Division of Infectious Diseases, University of California, San Francisco; Hospital Epidemiologist, San Francisco General Hospital

Lundy Campbell, MD

Professor, Department of Anesthesiology and Perioperative Medicine, University of California San Francisco, School of Medicine, San Francisco

Maria Almira Correia, PhD

Professor of Pharmacology, Pharmaceutical Chemistry and Biopharmaceutical Sciences, Department of Cellular & Molecular Pharmacology, University of California, San Francisco

Marieke Kruidering-Hall, PhD

Academy Chair in Pharmacology Education; Associate Professor, Department of Cellular and Molecular Pharmacology, University of California, San Francisco

Mark A. Schumacher, PhD, MD

Professor, Department of Anesthesia and Perioperative Care, University of California, San Francisco

Mark von Zastrow, MD, PhD

Professor, Departments of Psychiatry and Cellular & Molecular Pharmacology, University of California, San Francisco

Martha S. Nolte Kennedy, MD

Clinical Professor, Department of Medicine, University of California, San Francisco

Mary J. Malloy, MD

Clinical Professor of Pediatrics and Medicine, Departments of Pediatrics and Medicine, Cardiovascular Research Institute, University of California, San Francisco

Michael J. Aminoff, MD, DSc, FRCP

Professor, Department of Neurology, University of California, San Francisco

Michael J. Kosnett, MD, MPH

Associate Clinical Professor of Medicine, Division of Clinical Pharmacology and Toxicology, University of Colorado Health Sciences Center, Denver

Nabeel H. Borazan, MD

Department of Medicine, University of California, Los Angeles

Neal L. Benowitz, MD

Professor of Medicine and Bioengineering & Therapeutic Science, University of California, San Francisco, San Francisco

Nicholas H. G. Holford, MB, ChB, FRACP

Professor, Department of Pharmacology and Clinical Pharmacology, University of Auckland Medical School, Auckland

Paul W. Lofholm, PharmD

Clinical Professor of Pharmacy, School of Pharmacy, University of California, San Francisco

Philip J. Rosenthal, MD

Professor of Medicine, University of California, San Francisco, San Francisco General Hospital

Ramana K. Naidu, MD

Department of Anesthesia and Perioperative Care, University of California, San Francisco

Robin L. Corelli, PharmD

Clinical Professor, Department of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco

Roger A. Nicoll, MD

Professor of Pharmacology and Physiology, Departments of Cellular & Molecular Pharmacology and Physiology, University of California, San Francisco

Roger J. Porter, MD

Adjunct Professor of Neurology, University of Pennsylvania, Philadelphia; Adjunct Professor of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda

Samie R. Jaffrey, MD, PhD

Associate Professor of Pharmacology, Department of Pharmacology, Cornell University Weill Medical College, New York City

Sharon Safrin, MD

Associate Clinical Professor, Department of Medicine, University of California, San Francisco; President, Safrin Clinical Research

Spencer Yost, MD

Professor, Department of Anesthesia and Perioperative Care, University of California, San Francisco; Medical Director, UCSF-Mt. Zion ICU, Chief of Anesthesia, UCSF-Mt. Zion Hospital

Stephen M. Rosenthal, MD

Professor of Pediatrics, Associate Program Director, Pediatric Endocrinology; Director, Pediatric Endocrine Outpatient Services, University of California, San Francisco

Susan B. Masters, PhD

Associate Dean, School of Medicine; Professor of Pharmacology Department of Cellular & Molecular Pharmacology, University of California, San Francisco

Prefácio

A 13a edição de Farmacologia básica e clínica mantém as alterações importantes introduzidas na 11a edição, utilizando muitas ilustrações coloridas e ampliando as informações sobre transportadores, farmacogenômica e novos fármacos. Os estudos de casos e suas respectivas respostas ao final de cada capítulo tornam o processo de aprendizado ainda mais interessante. Como em edições anteriores, este livro foi projetado para ser abrangente, confiável e acessível para estudantes das ciências da saúde. São necessárias revisões frequentes para acompanhar as rápidas mudanças na farmacologia e terapêutica. Este livro também oferece tópicos especiais que fazem dele uma referência útil para estudantes, residentes e médicos na prática clínica.

As informações estão organizadas de acordo com a sequência utilizada em cursos e disciplinas de farmacologia e em currículos integrados: princípios básicos; fármacos autonômicos; fármacos cardiovasculares e renais; fármacos com ações importantes sobre o músculo liso; fármacos que agem no sistema nervoso central; fármacos usados no tratamento de doenças do sangue, inflamação e gota; fármacos endócrinos; fármacos quimioterápicos; toxicologia e tópicos especiais. Essa sequência adiciona novas informações sobre o conhecimento já assimilado. A apresentação antecipada da farmacologia do sistema nervoso autônomo permite que os estudantes integrem fisiologia e neurociências aprendidas a partir de outras fontes com a farmacologia que estão aprendendo, e os prepara para entender os efeitos autonômicos de outros fármacos. Isso é especialmente importante para os grupos de fármacos cardiovasculares e do sistema nervoso central. Entretanto, os capítulos podem ser igualmente utilizados em cursos e currículos que apresentem esses tópicos em uma sequência diferente.

(Parte 1 de 14)

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